XBIState Street SPDR S&P Biotech ETF
Grow my money#158 of 2944 for Grow my money
Seeks to provide investment results that correspond generally to the total return performance of an index derived from the biotechnology segment.
State Street Investment Management · Since 2006 (20 years)
Annual Cost
0.35%
#1517 out of 5,332 ETFs
Fund Size
$7.4B
#306 out of 5,332 ETFs
Dividend Yield
0.35%
Track Record
20 years
#277 out of 5,332 ETFs
Performance
1 Year
+57.8%
3 Years
+18.2%
5 Years
-1.2%
What's inside
Asset class
Region
Focus
Biotech & Genomics
Asset allocation
Stocks
99.9%
Cash
0.1%
Sector breakdown
Healthcare
99.8%
Financial Services
0.2%
Top holdings
Apellis Pharmaceuticals IncAPLS1.8%
Alkermes PLCALKS1.5%
Madrigal Pharmaceuticals IncMDGL1.4%
TG Therapeutics IncTGTX1.3%
Insmed IncINSM1.3%
Scholar Rock Holding CorpSRRK1.3%
Apogee Therapeutics IncAPGE1.3%
Protagonist Therapeutics IncPTGX1.2%
Summit Therapeutics Inc Ordinary SharesSMMT1.2%
United Therapeutics CorpUTHR1.2%
Risk profile
Volatility (1Y)
25.9%
High
Max drawdown
-63.9%
Worst peak-to-trough loss
Sharpe (3Y)
0.62
Decent risk-adjusted returns
Sortino (3Y)
0.92
Moderate downside risk
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Data updated on 2026-05-05